Key result
Ginsenoside compound K, but not its parent compound Rb1, significantly inhibited cell proliferation and induced apoptosis in human colorectal cancer cells.
Why the study?
Does Ginsenoside compound K inhibit proliferation and induce apoptosis in human colorectal cancer cells compared to Rb1?
Does Ginsenoside compound K inhibit proliferation and induce apoptosis in human colorectal cancer cells compared to Rb1?
p-value: p=<0.01
Ginsenoside compound K, an intestinal metabolite of Rb1, exhibits significant anti-proliferative and pro-apoptotic effects in human colorectal cancer cells, suggesting potential as a chemopreventive agent.
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Hypothesis-generating for compound K in colorectal cancer; should not change practice without clinical trials.
A 2012 study studied Colorectal cancer. Ginsenoside compound K vs. Ginsenoside Rb1 was evaluated on Cell proliferation inhibition at 30 µM in SW-480 cells (p=<0.01). Ginsenoside compound K, but not its parent compound Rb1, significantly inhibited cell proliferation and induced apoptosis in human colorectal cancer cells.
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