What question did this study set out to answer?

This study aims to explore the effectiveness of Ginsenoside Rg5 in inhibiting colorectal cancer and its underlying mechanisms.

February 7, 2026Scientific ReportsOpen Access

Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the lysosomal degradation of colorectal cancer cells

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Animal studies demonstrate Ginsenoside Rg5 reduces tumor growth and induces apoptosis in colorectal cancer, suggesting its role in adjuvant therapy.

This study aims to explore the effectiveness of Ginsenoside Rg5 in inhibiting colorectal cancer and its underlying mechanisms.
Used mouse models to evaluate tumor growth inhibition by Ginsenoside Rg5.
Measured autophagy-related proteins LC3-II and p62 in tumor tissues.
Investigated the role of V-ATPase in lysosomal degradation processes.
Ginsenoside Rg5 significantly inhibited tumor growth in mouse models of colorectal cancer.
Increased levels of autophagy-related proteins were observed in the tumors of Rg5-treated mice.
Rg5 inhibits lysosomal degradation by targeting ATP6V1A, blocking autophagic flux and inducing apoptosis.

Guo et al. (2026) studied this question.

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Animal studies demonstrate Ginsenoside Rg5 reduces tumor growth and induces apoptosis in colorectal cancer, suggesting its role in adjuvant therapy.