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August 26, 2019Analytical Cellular PathologyOpen Access

Rg3 significantly decreased orthotopic tumor growth and increased survival compared to control (P<0.05).

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Why the study?

Preliminary study showed ginsenoside Rg3 induces apoptosis in hepatocellular carcinoma in vitro, but the cross-link between apoptosis induction and antiangiogenesis effects on orthotopic HCC in vivo was uninvestigated.

Does ginsenoside Rg3 improve survival and inhibit tumor growth in a mouse model of orthotopic hepatocellular carcinoma?

Comparison

Oral ginsenoside Rg3 (10 mg/kg once a day for 30 days) vs control

Design

In vivo animal study

Authors

SHShen HuYZYan ZhuXXXiangyang Xia

Discussion

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Member takes

Overview

Does not support clinical use of Rg3 in HCC; leaves open translation from orthotopic mouse models.

Structured PICO

Does ginsenoside Rg3 improve survival and inhibit tumor growth in a mouse model of orthotopic hepatocellular carcinoma?

P
Population
20 mice with orthotopic hepatocellular carcinoma (murine HCC cells Hep1-6 implanted in the liver)
I
Intervention
Ginsenoside Rg3 10 mg/kg oral once a day for 30 days
C
Comparator
Control
O
Outcome
Survival and orthotopic tumor growthsurrogate

Ginsenoside Rg3 prolongs survival and reduces tumor growth in a mouse model of hepatocellular carcinoma by inducing apoptosis and inhibiting angiogenesis.

Cite This Study

Hu et al. (2019) studied this question.

synapsesocial.com/papers/6a8516da2ef56d2c2c9eaf43https://doi.org/10.1155/2019/3815786
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioinformatics and experimental verification to explore the potential mechanism of ginsenoside Rg3 suppresses hepatocellular carcinoma progression2024 · 5 citations
  2. 2Ginsenoside Rg3 attenuates hepatoma VEGF overexpression after hepatic artery embolization in an orthotopic transplantation hepatocellular carcinoma rat model2014 · 32 citations
  3. 3Ginsenoside Rg3 Combined with Oxaliplatin Inhibits the Proliferation and Promotes Apoptosis of Hepatocellular Carcinoma Cells &lt;i&gt;via&lt;/i&gt; Downregulating PCNA and Cyclin D12019 · 37 citations
  4. 4Gensenoside Rg3 Inhibits Hypoxia-induced VEGF Expression in Human Cancer Cells2010 · 81 citations
  5. 5Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer2007 · 89 citations