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October 1, 2014OncoTargets and TherapyOpen Access

Combined Rg3 and TAE treatment reduced tumor progression, angiogenesis, and metastasis rate, and improved overall survival, with VEGF expression at 4 weeks being 45.3±0.4 pg/mL in the TAE + Rg3 group compared to 87.4±0.7 pg/mL in the TAE group.

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Why the study?

Does combined ginsenoside Rg3 and transarterial embolization reduce tumor progression and angiogenesis in a rat model of hepatocellular carcinoma?

Population

Buffalo rats with an orthotopic transplantation hepatocellular carcinoma (HCC) model (n=60, 15 per group)

Comparison

Hepatic artery infusion of iodized oil with… vs Hepatic artery infusion of normal saline, Rg3…

Design

Preclinical

Follow-up

8 weeks

Authors

BZBo ZhouJWJianhua WangZYZhiping Yan

Discussion

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Overview

Preclinical support for Rg3 as TAE adjunct in HCC models; should not yet change practice pending human trials.

Structured PICO

Does combined ginsenoside Rg3 and transarterial embolization reduce tumor progression and angiogenesis in a rat model of hepatocellular carcinoma?

P
Population
Buffalo rats with an orthotopic transplantation hepatocellular carcinoma (HCC) model (n=60, 15 per group)
I
Intervention
Hepatic artery infusion of iodized oil (0.1 mL) with ginsenoside Rg3 (1 mg/kg) (TAE + Rg3)
C
Comparator
Hepatic artery infusion of normal saline (control), Rg3 alone (1 mg/kg), or iodized oil alone (0.1 mL) (TAE)
O
Outcome
Performance status (body weight), tumor progression (longest tumor diameter), metastasis rate, microvessel density (MVD), overall survival rate, and expression of CD31, VEGF, VEGF-R2, and VEGF-R2 phosphorylation at 1, 2, 4, and 8 weekssurrogate

In a rat model of hepatocellular carcinoma, combining ginsenoside Rg3 with transarterial embolization attenuated hypoxia-induced VEGF overexpression, reduced metastasis, and improved survival.

Cite This Study

Zhou et al. (2014) studied this question.

synapsesocial.com/papers/6a8516dd2ef56d2c2c9eaf51https://doi.org/10.2147/ott.s69830
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Also Consider

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  1. 1Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis2019 · 29 citations
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