Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2010Cellular Physiology and BiochemistryOpen Access

Ginsenoside Rg3 inhibited hypoxia-induced VEGF expression, cell proliferation, and multiple signaling pathways (HIF-1α, COX-2, NF-κB, STAT3, ERK1/2, JNK) in human cancer cells.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Ginsenoside Rg3 inhibit hypoxia-induced VEGF expression in human cancer cells?

Population

Human esophageal carcinoma cell line Eca-109 and 786-0 cells

Comparison

Ginsenoside Rg3 vs Untreated cells under normoxic and hypoxic…

Design

Preclinical

Key result

Ginsenoside Rg3 inhibited hypoxia-induced VEGF expression, cell proliferation, and multiple signaling pathways (HIF-1α, COX-2, NF-κB, STAT3, ERK1/2, JNK) in human cancer cells.

Authors

QCQingjiang ChenMZMingzhi ZhangLWLexin Wang

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for anti-angiogenic effects in cancer; leaves open clinical translation pending human trials.

Structured PICO

Does Ginsenoside Rg3 inhibit hypoxia-induced VEGF expression in human cancer cells?

P
Population
Human esophageal carcinoma cell line Eca-109 and 786-0 cells
I
Intervention
Ginsenoside Rg3
C
Comparator
Untreated cells under normoxic and hypoxic conditions
O
Outcome
VEGF expression (mRNA and protein) and cell proliferationsurrogate

Ginsenoside Rg3 down-regulates VEGF expression in cancer cells by targeting multiple hypoxia-induced signaling pathways, providing a mechanistic basis for its anti-angiogenic and anti-tumor efficacy.

Cite This Study

Chen et al. (2010) studied Human esophageal carcinoma and renal cell carcinoma (Eca-109 and 786-0 cells). Ginsenoside Rg3 was evaluated on VEGF expression, cell proliferation, and signaling pathway activation. Ginsenoside Rg3 inhibited hypoxia-induced VEGF expression, cell proliferation, and multiple signaling pathways (HIF-1α, COX-2, NF-κB, STAT3, ERK1/2, JNK) in human cancer cells.

synapsesocial.com/papers/6a7b63cdbdf697b3de02f28fhttps://doi.org/10.1159/000323994
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis2011 · 68 citations
  2. 2Ginsenoside Rg3 attenuates hepatoma VEGF overexpression after hepatic artery embolization in an orthotopic transplantation hepatocellular carcinoma rat model2014 · 32 citations
  3. 3Ginsenoside Rg3 Inhibits Endothelial Progenitor Cell Differentiation through Attenuation of VEGF‐Dependent Akt/eNOS Signaling2012 · 28 citations
  4. 4Ginsenoside Rg3 inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules in human endothelial cells2010
  5. 5Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis2019 · 29 citations