Key result
Ginsenoside Rg3 inhibited endothelial progenitor cell differentiation, migration, and tube formation by attenuating VEGF-dependent Akt/eNOS signaling in vitro.
Why the study?
Does ginsenoside Rg3 inhibit endothelial progenitor cell differentiation and angiogenesis in vitro?
Population
CD34⁺ cells isolated from human cord blood
Design
Preclinical
Authors
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Hypothesis-generating for ginsenoside Rg3 as angiogenesis inhibitor; leaves open clinical translation pending in vivo trials.
Does ginsenoside Rg3 inhibit endothelial progenitor cell differentiation and angiogenesis in vitro?
Ginsenoside Rg3 acts as a potential angiogenesis inhibitor by attenuating endothelial progenitor cell differentiation and bioactivities via the VEGF-dependent Akt/eNOS signaling pathway in vitro.
Kim et al. (2012) studied this question. Ginsenoside Rg3 was evaluated on EPC bioactivities including cell proliferation, differentiation, migration and tube formation. Ginsenoside Rg3 inhibited endothelial progenitor cell differentiation, migration, and tube formation by attenuating VEGF-dependent Akt/eNOS signaling in vitro.
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