Key result
Ginsenoside Rg1 promoted endothelial progenitor cell proliferation and vasculogenesis in dose- and time-dependent manners, and increased telomerase activity, inhibiting senescence in vitro.
Ginsenoside Rg1 enhances proliferation and angiogenesis while inhibiting senescence in endothelial progenitor cells in vitro.
Hypothesis-generating for ginsenoside Rg1 in endothelial repair; leaves open clinical translation pending in vivo studies.
This study investigated the effect of ginsenoside Rg1 on the functions of ex vivo cultivated endothelial progenitor cells (EPCs) and whether ginsenoside Rg1 prevented EPC senescence. EPCs isolated from peripheral blood from healthy volunteers were incubated with different concentrations of ginsenoside Rg1 and the effects were observed at different time points. Cell proliferation and in vitro vasculogenesis were assayed and flow cytometry was used to determine the effects of ginsenoside Rg1 on the cell cycle. Senescence and telomerase activity in EPCs were also assayed. It was found that ginsenoside Rg1 promoted EPC proliferation and vasculogenesis in dose-and time-dependent manners. Cell-cycle analysis showed that ginsenoside Rg1 increased the proliferative phase and decreased the resting phase of EPCs. β-Galactosidase and telomerase activities increased. These results support the view that ginsenoside Rg1 induces EPC proliferation and angiogenesis, and inhibits EPC senescence.
No takes yet. Share an insight, caveat, or question.
Gu et al. (2011) studied Healthy volunteers (Endothelial Progenitor Cells). Ginsenoside Rg1 was evaluated on EPC proliferation, vasculogenesis, cell cycle, senescence, and telomerase activity. Ginsenoside Rg1 promoted endothelial progenitor cell proliferation and vasculogenesis in dose- and time-dependent manners, and increased telomerase activity, inhibiting senescence in vitro.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: