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July 23, 2009BMC CancerOpen Access

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

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Why the study?

Does the combination of ginsenoside Rg3 and gemcitabine reduce tumor growth and angiogenesis in mice with Lewis lung carcinoma?

Population

40 female C57BL/6 mice (6-8 weeks old, 18-20g) implanted with Lewis lung carcinoma cells (n=40, 10 per group).

Comparison

Ginsenoside Rg3 combined with gemcitabine for 18… vs Control, gemcitabine alone, and ginsenoside Rg3…

Design

Preclinical, randomized into the following four groups, All counts were…

Follow-up

18 days

Authors

TLTai-Guo LiuYHYing HuangDCDandan Cui

Discussion

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Overview

Supports preclinical synergy in lung cancer models; leaves open translation to human trials.

Structured PICO

Does the combination of ginsenoside Rg3 and gemcitabine reduce tumor growth and angiogenesis in mice with Lewis lung carcinoma?

P
Population
40 female C57BL/6 mice (6-8 weeks old, 18-20g) implanted with Lewis lung carcinoma cells (n=40, 10 per group).
I
Intervention
Ginsenoside Rg3 (20 mg/kg daily via gastric perfusion) combined with gemcitabine (10 mg/kg intraperitoneally every 3rd day) for 18 days.
C
Comparator
Control (normal saline subcutaneously), gemcitabine alone (10 mg/kg intraperitoneally every 3rd day), and ginsenoside Rg3 alone (20 mg/kg daily via gastric perfusion).
O
Outcome
Tumor growth (volume and inhibitive rate) and survival at 18 days.surrogate

The combination of ginsenoside Rg3 and gemcitabine synergistically inhibits tumor angiogenesis and growth while improving survival in a mouse model of lung cancer.

Cite This Study

Liu et al. (2009) studied this question.

synapsesocial.com/papers/6a7717f44fe2e6ffd8ec67bdhttps://doi.org/10.1186/1471-2407-9-250
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Also Consider

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