Why the study?
The study aimed to investigate the effects of ginsenoside Rg3 combined with oxaliplatin on hepatocellular carcinoma cell proliferation and apoptosis, and the related mechanism.
Does ginsenoside Rg3 combined with oxaliplatin inhibit proliferation and promote apoptosis in hepatocellular carcinoma cells?
Population
Hepatocellular carcinoma cell SMMC-7721
Comparison
Ginsenoside Rg3 + oxaliplatin vs ginsenoside Rg3 alone vs oxaliplatin alone
Design
In vitro laboratory study
Authors
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Supports further exploration of ginsenoside Rg3-oxaliplatin in hepatocellular carcinoma; leaves open clinical translation pending in vivo and human studies.
Does ginsenoside Rg3 combined with oxaliplatin inhibit proliferation and promote apoptosis in hepatocellular carcinoma cells?
The combination of ginsenoside Rg3 and oxaliplatin synergistically inhibits proliferation and promotes apoptosis in hepatocellular carcinoma cells by downregulating PCNA and cyclin D1.
Shan et al. (2019) studied this question.
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