Key result
UTE-MT modeling with measured T1 provided robust macromolecular fraction estimates with <3% error for fat fractions <20%, whereas constant T1 models were robust only for fat fractions <10%.
Why the study?
Fat present in muscle has been a source of concern in macromolecular fraction calculation, prompting investigation into the impact of fat fraction on estimated macromolecular fraction.
Population
Bovine skeletal muscle phantoms embedded in pure fat
Comparison
UTE-MT modeling with vs without T1 measurement and B1 correction across differing fat fractions
Design
Phantom study
Authors
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Animal data support T1-corrected MMF for moderate fat infiltration; leaves open translation to clinical practice.
UTE-MT modeling with accurate T1 measurement allows for robust skeletal muscle assessment that remains insensitive to fat infiltration up to moderate levels.
Jerban et al. (2023) studied Skeletal muscle assessment (phantom study). UTE-MT modeling with measured T1 vs. UTE-MT modeling with constant T1 was evaluated on Macromolecular fraction (MMF) estimation accuracy across differing fat fractions. UTE-MT modeling with measured T1 provided robust macromolecular fraction estimates with <3% error for fat fractions <20%, whereas constant T1 models were robust only for fat fractions <10%.
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