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November 1, 2008Journal of Clinical HypertensionOpen Access

Using Diuretics in Practice—One Opinion

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Population

Patients with hypertension

Comparison

Diuretic-based antihypertensive regimens… vs Hydrochlorothiazide or non-diuretic…

Design

Review

Authors

WEW.J. ElliottGeneral / Preventive / LipidsRGRichard H. GrimmGeneral Cardiology

Discussion

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Implication

May support chlorthalidone preference in hypertension; leaves open need for contemporary outcome trials.

Structured PICO

P
Population
Patients with hypertension
I
Intervention
Diuretic-based antihypertensive regimens, specifically chlorthalidone (12.5-25 mg/d) or loop diuretics for patients with eGFR <40 mL/min/1.73 m2
C
Comparator
Hydrochlorothiazide or non-diuretic antihypertensive agents (e.g., ACE inhibitors, calcium channel blockers)
O
Outcome
Blood pressure reduction and prevention of major cardiovascular disease events

This commentary argues that chlorthalidone should be preferred over hydrochlorothiazide for hypertension management due to its superior blood pressure-lowering potency and stronger evidence base for preventing cardiovascular events.

Cite This Study

Elliott et al. (2008) studied this question.

synapsesocial.com/papers/6a818ea8ad4cc96147a1e209https://doi.org/10.1111/j.1751-7176.2008.00029.x

Topics

Hypertension management
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