What question did this study set out to answer?

To investigate the time course of the development and subsequent regression of exercise-induced cardiac hypertrophy and associated cellular markers.

February 1, 1979AJP Heart and Circulatory Physiology

Development and regression of exercise-induced cardiac hypertrophy in rats

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Population

Adult female rats

Comparison

Daily swimming exercise for up to 21 days vs Sedentary control

Design

Preclinical

Follow-up

21 days of exercise followed by various time intervals…

Authors

RHR. C. HicksonIllinois College GHGlenn T. HammonsUniversity of Iowa JHJ. O. Holoszy

Discussion

Member takes

Implication

Animal findings of rapid exercise hypertrophy reversal with persistent fibrosis marker leave open human translational relevance.

Key Points

To investigate the time course of the development and subsequent regression of exercise-induced cardiac hypertrophy and associated cellular markers.
Adult female rats engaged in daily swimming protocols for up to 14 to 21 days.
Assessed cardiac weight, total protein, cytochrome c (mitochondrial marker), DNA, and hydroxyproline (connective tissue hyperplasia marker) during exercise and at serial time intervals after exercise cessation.
Exercise induced an average 30% increase in heart weight within 14 days, with half-times of ~4.5 days for heart weight and total protein, and 6.5 days for cytochrome c.
DNA and hydroxyproline contents increased slightly during hypertrophy development by 8% and 10%, respectively.
Following exercise cessation, 60% of hypertrophy regression occurred in the first week, while elevated hydroxyproline levels remained unchanged.

Structured PICO

Population

Adult female rats

Intervention

Daily swimming exercise for up to 21 days

Comparator

Sedentary control

Outcome

Changes in heart weight, total protein content, cytochrome c, DNA, and hydroxyprolinesurrogate

Exercise-induced cardiac hypertrophy in rats develops rapidly and regresses quickly upon cessation, except for connective tissue hyperplasia which persists.

Cite This Study

Hickson et al. (1979) studied this question.

synapsesocial.com/papers/6a819140d433ecbb06e1d4cd https://doi.org/10.1152/ajpheart.1979.236.2.h268

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Development and regression of exercise-induced cardiac hypertrophy in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Development and regression of exercise-induced cardiac hypertrophy in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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