Key result
Growth hormone administration in GH-deficient individuals may induce short-term insulin resistance and impaired fasting glucose, though long-term effects on diabetes risk require further study.
Why the study?
Does growth hormone administration alter glucose metabolism and insulin resistance in humans?
Population
Humans (adults, children, and adolescents) with growth hormone deficiency
Design
Review
Authors
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May warrant glucose monitoring in GH-deficient patients on therapy; leaves open long-term diabetes risk.
Does growth hormone administration alter glucose metabolism and insulin resistance in humans?
Growth hormone therapy can induce insulin resistance and increase the risk of type 2 diabetes in susceptible individuals, highlighting the need for metabolic monitoring during treatment.
Kim et al. (2017) conducted a review in Growth hormone deficiency. Growth hormone was evaluated. Growth hormone administration in GH-deficient individuals may induce short-term insulin resistance and impaired fasting glucose, though long-term effects on diabetes risk require further study.
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