Key result
The AT1R A1166C gene polymorphism (AC and CC genotypes) was significantly more frequent in adult Egyptian hemodialysis patients compared to controls.
Why the study?
Is the AT1R A1166C gene polymorphism associated with end-stage renal disease and hypertension in Egyptian adults?
Case-Control (n=202)
Is the AT1R A1166C gene polymorphism associated with end-stage renal disease and hypertension in Egyptian adults?
The AT1R A1166C gene polymorphism (CC/AC genotype) is associated with end-stage renal disease requiring hemodialysis in Egyptian adults, but not with hypertension in this population.
AT1R A1166C polymorphism was associated with ESRD requiring hemodialysis in Egyptians; hypothesis-generating, leaves open hypertension link and clinical utility.
BackgroundGenetic variability in the genes of different components of renin-angiotensin system (RAS) is likely to contribute for its heterogenous association in renal diseased patients. Among the candidate genes of RAS, angiotensin II type 1 receptor gene polymorphism (AT1R A1166C) seems to be particularly biologically and clinically relevant to renal diseases.The aimThis study was to evaluate the association of AT1R A1166C gene polymorphism in adult Egyptian hemodialysis (HD) patients. Its association with hypertension was also done.Subjects and methodsThe study was conducted on 202 adult Egyptian subjects: 100 controls and 102 HD patients. Determination of this polymorphism was done by PCR/RFLP strategy.ResultsIt revealed that HD patients had significantly higher frequency in AC and CC genotypes than controls. But on dividing these patients to normotensive and hypertensive ones, no significant difference in the genotypes was found. The multiple regression analysis revealed no dependent variables on the AT1R A1166C gene polymorphism.ConclusionThis study suggested that CC/AC genotype could serve as a predictor of an early end-stage renal disease (ESRD) and could, in the future, become an important part of the clinical process of renal risk identification.
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El-Banawy et al. (2015) conducted a case-control in Hemodialysis / End-stage renal disease (n=202). AT1R A1166C gene polymorphism vs. Controls was evaluated on Frequency of AT1R A1166C genotypes (AC and CC). The AT1R A1166C gene polymorphism (AC and CC genotypes) was significantly more frequent in adult Egyptian hemodialysis patients compared to controls.
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