Key result
The presence of the T allele in the ATR1 (A1166C) gene polymorphism, whether in a homozygous or heterozygous state, was associated with a positive risk of developing essential hypertension.
Why the study?
Is the Angiotensin II type 1 receptor (A1166C) gene polymorphism associated with an increased risk of essential hypertension in an Egyptian population?
Case-Control (n=143)
Is the Angiotensin II type 1 receptor (A1166C) gene polymorphism associated with an increased risk of essential hypertension in an Egyptian population?
The ATR1 (A1166C) gene polymorphism is associated with an increased risk of essential hypertension in the Egyptian population.
Answers are grounded in this paper and cite their sources.
Supports genetic evaluation in Egyptians; extends ATR1 evidence but leaves clinical adoption open.
The pathogenesis of essential hypertension (EH) is affected by genetic and environmental factors. Mutations in hypertension-related genes can affect blood pressure (BP) via alteration of salt and water reabsorption by the nephron. The genes of the renin-angiotensin system (RAS) have been extensively studied because of the well documented role of this system in the control of BP. It has been previously shown that Angiotensin II type 1 receptor (ATR1) gene polymorphism could be associated with increased risk of EH. So, in the current study, we evaluated the frequency of ATR1 (A1166C) polymorphism in relation to EH in a group of Egyptian population. The study population included 83 hypertensive patients and 60 age and sex matched healthy control subjects. Restriction fragment length polymorphism – Polymerase chain reaction (RFLP – PCR) was used for the analysis of A1166C polymorphism of ATR1 genes in peripheral blood samples of all patients and controls. The results revealed that there was a positive risk of developing EH when having the T allele whether in homozygous or heterozygous state. From this work, it was concluded that there was an association between ATR1 (A1166C) gene polymorphism and the risk of developing EH.
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Shamaa et al. (2016) conducted a case-control in Essential hypertension (n=143). ATR1 (A1166C) gene polymorphism (T allele) vs. Absence of T allele / healthy controls was evaluated on Risk of developing essential hypertension. The presence of the T allele in the ATR1 (A1166C) gene polymorphism, whether in a homozygous or heterozygous state, was associated with a positive risk of developing essential hypertension.
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