Key result
In a study of 143 Egyptian individuals, the T allele of the AGT (M235T) gene polymorphism was associated with an increased risk of developing essential hypertension.
Why the study?
Is the AGT (M235T) gene polymorphism associated with an increased risk of essential hypertension in Egyptian patients?
Case-Control (n=143)
Is the AGT (M235T) gene polymorphism associated with an increased risk of essential hypertension in Egyptian patients?
The AGT (M235T) gene polymorphism, specifically the presence of the T allele, is associated with an increased risk of essential hypertension in the Egyptian population.
Answers are grounded in this paper and cite their sources.
May inform risk assessment in Egyptians; leaves open clinical utility of AGT testing.
The pathogenesis of essential hypertension (EH) is affected by genetic and environmental factors. Mutations in hypertension-related genes can affect blood pressure (BP) via alteration of salt and water reabsorption by the nephron. The genes of the renin-angiotensin system (RAS) have been extensively studied because of the well documented role of this system in the control of BP. It has been previously shown that angiotensinogen (AGT) gene polymorphism could be associated with increased risk of EH. The current study evaluated the frequency of AGT (M235T) polymorphism in relation to EH in a group of Egyptian population. The study population included 83 hypertensive patients and 60 age and sex matched healthy control subjects. Restriction fragment length polymorphism-Polymerase chain reaction (RFLP-PCR) was used for the analysis of M235T polymorphism of AGT genes in peripheral blood samples of all patients and controls. The results revealed that there was a positive risk of developing EH when having the T allele whether in homozygous or heterozygous state. It was concluded that there was an association between AGT (M235T) gene polymorphism and the risk of developing EH.
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Shamaa et al. (2013) conducted a case-control in Essential Hypertension (n=143). AGT (M235T) gene polymorphism (T allele) vs. Healthy controls / absence of T allele was evaluated on Risk of developing essential hypertension. In a study of 143 Egyptian individuals, the T allele of the AGT (M235T) gene polymorphism was associated with an increased risk of developing essential hypertension.
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