Key result
The AT1R A1166C gene CC genotype was associated with a higher risk of end-stage renal disease in African populations (OR 3.36; 95% CI 1.42-7.99; p=0.006), but not in the overall population.
Why the study?
Is the angiotensin II type-1 receptor (AT1R) A1166C gene polymorphism associated with susceptibility to end-stage renal disease?
Meta-Analysis
Is the angiotensin II type-1 receptor (AT1R) A1166C gene polymorphism associated with susceptibility to end-stage renal disease?
Odds Ratio: 3.36 (95% CI 1.42–7.99)
p-value: p=0.006
The AT1R A1166C gene polymorphism (CC genotype) may be a risk factor for ESRD susceptibility specifically in African populations, despite no overall association.
May inform ancestry-specific ESRD risk assessment in Africans; leaves open broader applicability and prospective validation.
Association between angiotensin II type-1 receptor (AT1R) A1166C gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. This meta-analysis was performed to evaluate the association of AT1R A1166C gene polymorphism with ESRD susceptibility. The search was performed in the databases of PubMed, Embase and Cochrane Library as of 1 May 2012, and the eligible investigations were recruited for this meta-analysis. Nineteen literatures were identified for the analysis of association between AT1R A1166C gene polymorphism and ESRD susceptibility. There was no association between AT1R A1166C gene polymorphism and ESRD susceptibility for overall populations, Caucasians, Asians and Turkish population. Interestingly, CC genotype was associated with a higher risk of ESRD in Africans (OR = 3.36, 95% CI: 1.42-7.99, p = 0.006). However, C allele and AA genotype were not associated with the ESRD risk in African population. In conclusion, CC genotype might be a risk factor for the ESRD susceptibility in African population. However, more case-control association investigations on larger, stratified populations are required in the future.
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Zhou et al. (2013) conducted a meta-analysis in End-stage renal disease. AT1R A1166C gene polymorphism (CC genotype) vs. Other genotypes was evaluated on End-stage renal disease susceptibility (OR 3.36, 95% CI 1.42-7.99, p=0.006). The AT1R A1166C gene CC genotype was associated with a higher risk of end-stage renal disease in African populations (OR 3.36; 95% CI 1.42-7.99; p=0.006), but not in the overall population.
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