Key result
ACE D allele carriers had a significantly increased risk of developing high-altitude pulmonary edema compared to II genotype carriers (OR 1.55; 95% CI 1.15-2.08; p=0.004).
Why the study?
Does the ACE D allele increase the risk of developing high-altitude pulmonary oedema compared to the I allele?
Meta-Analysis (n=967)
Does the ACE D allele increase the risk of developing high-altitude pulmonary oedema compared to the I allele?
Answers are grounded in this paper and cite their sources.
The ACE D allele is associated with a significantly increased risk of developing high-altitude pulmonary oedema.
BACKGROUND AND OBJECTIVE: High-altitude pulmonary oedema (HAPE) is a non-cardiogenic hydrostatic oedema involving a genetic component. Considering the low incidence of HAPE, sample sizes in current reports are relatively limited. We aimed to assess the association between the angiotensin-converting enzyme (ACE) I/D polymorphism and HAPE via a meta-analysis of published and unpublished data. MATERIALS AND METHODS: We searched PubMed, CBM, CNKI, and Cochrane Library Database before 20 November 2010. A random-effects model was applied (STATA) and study quality was assessed in duplicate. RESULTS: A total of five studies including 305 cases and 662 controls were meta-analysed. The summary odds ratio (OR) indicated that no significant differences in risk of developing HAPE were found between carriers of ACE D and I alleles (OR = 1.20; 95% confidence interval (CI), 0.98-1.48; p = 0.084). Lack of association persisted for genotypes under the recessive mode. However, genotype association under the dominant mode showed D allele carriers significantly conferred a 1.55-fold increased HAPE risk compared with II genotype carriers (95% CI, 1.15-2.08; p = 0.004). Funnel plot and Egger's test suggested no evidence of publication bias. CONCLUSIONS: Our results supported the notion that ACE D allele carriers were at significant increased risk of developing HAPE.
No takes yet. Share an insight, caveat, or question.
Qi et al. (2011) conducted a meta-analysis in High-altitude pulmonary oedema (HAPE) (n=967). ACE D allele vs. ACE II genotype was evaluated on High-altitude pulmonary oedema (OR 1.55, 95% CI 1.15-2.08, p=0.004). ACE D allele carriers had a significantly increased risk of developing high-altitude pulmonary edema compared to II genotype carriers (OR 1.55; 95% CI 1.15-2.08; p=0.004).
Synapse has enriched 10 related papers. Consider them for comparative context: