June 1, 2009The International Journal of Artificial Organs

Smooth Muscle-Dependent Changes in Aortic Wall Dynamics during Intra-Aortic Counterpulsation in an Animal Model of Acute Heart Failure

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Why the study?

Does intra-aortic balloon pumping improve aortic wall mechanics and hemodynamics in an animal model of acute heart failure?

Population

6 anesthetized sheep with acute cardio-depression induced by halothane (4%)

Comparison

Intra-aortic balloon pumping (IABP) (1:2) vs Before IABP (baseline measurements)

Design

Preclinical

Authors

EFEdmundo I. Cabrera FischerFavaloro University DBDaniel BiaVascular Medicine YZYanina ZócaloPediatric Cardiology

Discussion

Member takes

Implication

Hypothesis-generating for IABP effects on aortic mechanics in acute HF; human trials needed before clinical consideration.

Structured PICO

Does intra-aortic balloon pumping improve aortic wall mechanics and hemodynamics in an animal model of acute heart failure?

Population

6 anesthetized sheep with acute cardio-depression induced by halothane (4%)

Intervention

Intra-aortic balloon pumping (IABP) (1:2)

Comparator

Before IABP (baseline measurements)

Outcome

Aortic wall mechanics (aortic characteristic impedance, incremental elastic modulus, stiffness index, Peterson elastic modulus) and hemodynamics (aortic pressure, cardiac output, systemic vascular resistances)surrogate

In an animal model of acute heart failure, IABP improves arterial functional capability and reduces left ventricular afterload by modulating aortic wall impedance and intrinsic stiffness.

Cite This Study

Fischer et al. (2009) studied this question.

synapsesocial.com/papers/6a8198385d6bc1011b4cd5ac https://doi.org/10.1177/039139880903200606

Topics

Heart failure HFrEF treatment

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Smooth Muscle-Dependent Changes in Aortic Wall Dynamics during Intra-Aortic Counterpulsation in an Animal Model of Acute Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Smooth Muscle-Dependent Changes in Aortic Wall Dynamics during Intra-Aortic Counterpulsation in an Animal Model of Acute Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider