Why the study?
Does central administration of superoxide dismutase mimetics prevent sympathetic nervous system activation and blood pressure increase in a rat model of phenol-induced renal injury?
Population
Rat model of phenol-induced renal injury hypertension
Comparison
Infusion of superoxide dismutase mimetics in the… vs Control rats
Design
Preclinical
Authors
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Hypothesis-generating for central ROS in sympathetic hypertension; prospective studies needed before clinical translation.
Does central administration of superoxide dismutase mimetics prevent sympathetic nervous system activation and blood pressure increase in a rat model of phenol-induced renal injury?
Central activation of the sympathetic nervous system in the phenol-renal injury model is mediated by increased reactive oxygen species in brain nuclei involved in the noradrenergic control of blood pressure.
Ye et al. (2006) studied this question.
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