What question did this study set out to answer?

To determine whether localized renal injury caused by intrarenal phenol injection induces permanent hypertension and whether this response is mediated by chronic sympathetic nervous system activation.

June 1, 1998American Journal of Hypertension

A Limited Renal Injury May Cause a Permanent Form of Neurogenic Hypertension

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Authors

SYShaohua YePLA Electronic Engineering Institute MGMichael GamburdUniversity of Southern California PMPantea MozayeniUniversity of Southern California

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Implication

Renal injury may sustain neurogenic hypertension via sympathetic activation in this model; leaves open relevance to human CKD hypertension.

Key Points

To determine whether localized renal injury caused by intrarenal phenol injection induces permanent hypertension and whether this response is mediated by chronic sympathetic nervous system activation.
Administered an intrarenal injection of 50 µL of 10% phenol or vehicle in rats, including a comparison cohort subjected to renal denervation.
Evaluated chronic effects 4 weeks post-injection by measuring systolic blood pressure and posterior hypothalamic norepinephrine secretion.
Systolic blood pressure increased significantly from 128 ± 2.1 to 176 ± 1.5 mm Hg (P < .01) at 4 weeks in phenol-treated rats, while remaining unchanged in vehicle controls (128 ± 2.4 to 135 ± 1.7 mm Hg) and denervated rats (127 ± 3.4 to 124 ± 1.0 mm Hg).
Norepinephrine secretion from the posterior hypothalamic nuclei was significantly higher in phenol-treated rats (253 ± 9.6 pg/mL) than in controls (158 ± 8.6 pg/mL) and denervated rats (170 ± 2.1 pg/mL; P < .01).

Cite This Study

Ye et al. (1998) studied this question.

synapsesocial.com/papers/6a7170a8febe604dd70a1bfe https://doi.org/10.1016/s0895-7061(98)00030-2

Topics

Hypertension management

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Implication

Renal injury may sustain neurogenic hypertension via sympathetic activation in this model; leaves open relevance to human CKD hypertension.

A Limited Renal Injury May Cause a Permanent Form of Neurogenic Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

A Limited Renal Injury May Cause a Permanent Form of Neurogenic Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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