What question did this study set out to answer?

To evaluate and compare the renal functional and neural reflex responses triggered by renal mechanoreceptor and chemoreceptor stimulation in dogs and rats.

January 1, 1984AJP Renal Physiology

Renorenal reflex responses to mechano- and chemoreceptor stimulation in the dog and rat

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Population

Dogs and rats

Design

Preclinical

Authors

UKUlla C. KoppUniversity of Iowa GDGerald F. DiBonaGeneral Cardiology

Discussion

Member takes

Implication

Species-specific renorenal reflexes in dogs and rats should not guide human care; leaves open their existence and function in clinical renal physiology.

Key Points

To evaluate and compare the renal functional and neural reflex responses triggered by renal mechanoreceptor and chemoreceptor stimulation in dogs and rats.
Stimulated mechanoreceptors by raising ureteral pressure or renal venous pressure, and chemoreceptors via retrograde ureteropelvic perfusion with 0.9 M NaCl in dogs and rats.
Measured ipsilateral and contralateral renal blood flow, glomerular filtration rate, renin secretion rate, urinary sodium excretion, and afferent and efferent renal nerve activity before and after renal denervation.
In dogs, mechanoreceptor activation decreased contralateral renal blood flow without altering contralateral excretion or renin secretion, while chemoreceptor stimulation produced no detectable functional response.
In rats, mechanoreceptor and chemoreceptor stimulation significantly increased contralateral urine flow rate and urinary sodium excretion while elevating ipsilateral afferent and suppressing contralateral efferent renal nerve activity.
Ipsilateral or contralateral renal denervation abolished the contralateral diuretic and natriuretic responses in rats, demonstrating an inhibitory renorenal reflex absent in dogs.

Structured PICO

Population

Dogs and rats

Intervention

Renal mechano- (MR) and chemoreceptor (CR) stimulation via increasing ureteral pressure, increasing renal venous pressure, and retrograde ureteropelvic perfusion with 0.9 M NaCl

Outcome

Renal functional effects including renal blood flow, renin secretion rate, urine flow rate, urinary sodium excretion, and renal nerve activitysurrogate

Renal mechanoreceptor and chemoreceptor stimulation elicit species-specific renorenal reflex responses, being excitatory in dogs and inhibitory in rats.

Cite This Study

Kopp et al. (1984) studied this question.

synapsesocial.com/papers/6a819d110dbb8263c158bfbb https://doi.org/10.1152/ajprenal.1984.246.1.f67

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Implication

Species-specific renorenal reflexes in dogs and rats should not guide human care; leaves open their existence and function in clinical renal physiology.

Renorenal reflex responses to mechano- and chemoreceptor stimulation in the dog and rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renorenal reflex responses to mechano- and chemoreceptor stimulation in the dog and rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider