Key result
Renorenal reflex responses to renal mechano- and chemoreceptor stimulation vary by species and are attenuated in spontaneously hypertensive rats, potentially contributing to hypertension.
Population
Anesthetized dogs, cats, and rats (including spontaneously hypertensive rats)
Comparison
Renal mechanoreceptor stimulation via increased… vs Unstimulated state; normotensive rats compared…
Design
Preclinical
Authors
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Renorenal reflex attenuation in hypertensive rat models should not yet inform practice; hypothesis-generating for species differences in hypertension mechanisms.
Species differences exist in renorenal reflex responses, and their attenuation in spontaneously hypertensive rats suggests a mechanism contributing to hypertension via sodium retention.
Kopp et al. (1987) studied Normotension and Hypertension. Renal mechano- and chemoreceptor stimulation was evaluated on Renorenal reflex responses (afferent/efferent renal nerve activity, mean arterial pressure, urine flow rate, urinary sodium excretion). Renorenal reflex responses to renal mechano- and chemoreceptor stimulation vary by species and are attenuated in spontaneously hypertensive rats, potentially contributing to hypertension.
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