What question did this study set out to answer?

To construct an open, standardized 3D Human Reference Atlas that describes the multiscale architecture of the healthy adult body across organs, tissues, cells, and biomarkers.

March 13, 2025Nature MethodsOpen Access

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

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To construct an open, standardized 3D Human Reference Atlas that describes the multiscale architecture of the healthy adult body across organs, tissues, cells, and biomarkers.
Collaborated across 20+ consortia to build a Common Coordinate Framework, biological knowledge graphs, and flexible hybrid cloud infrastructure.
Established workflows to integrate new experimental data via cell type annotation tools like Azimuth, validated antibody panels, and spatial tissue registration.
Released Human Reference Atlas version 2.0, cataloging 4,499 unique anatomical structures, 1,195 cell types, and 2,089 biomarkers such as genes, proteins, and lipids.
Integrated 33 ASCT+B tables and 65 3D Reference Objects linked directly to biological ontologies and unified computational pipelines.

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Implication

Consortium initiative demonstrates a multiscale 3D Human Reference Atlas in healthy adults, highlighting standardized cellular and spatial mapping across human organs.

Cite This Study

Börner et al. (2025) studied this question.

synapsesocial.com/papers/6a819d2b0f00bf78d4f1f99d https://doi.org/10.1038/s41592-024-02563-5

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Implication

Consortium initiative demonstrates a multiscale 3D Human Reference Atlas in healthy adults, highlighting standardized cellular and spatial mapping across human organs.

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

Key Points

Discussion

Implication

Cite This Study

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

Key Points

Discussion

Implication

Cite This Study

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