What question did this study set out to answer?

To review the principles and applications of threshold tracking techniques for assessing peripheral nerve excitability, axonal membrane potential, and ion channel function in vivo.

February 1, 1998Muscle & Nerve

Threshold tracking techniques in the study of human peripheral nerve

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Authors

HBHugh BostockNational Hospital for Neurology and Neurosurgery KCKatia CikurelThe King's College DBDavid BurkeEmory University

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Implication

Review shows threshold tracking assesses axonal membrane excitability and ion channel activity in human nerves, indicating strong diagnostic utility in metabolic and toxic neuropathies.

Key Points

To review the principles and applications of threshold tracking techniques for assessing peripheral nerve excitability, axonal membrane potential, and ion channel function in vivo.
Evaluated in vivo electrophysiological protocols comparing resting nerve excitation thresholds with alterations induced by ischemia, previous single impulses (refractoriness and superexcitability), impulse trains, or subthreshold currents (threshold electrotonus).
Surveyed clinical research using threshold tracking across peripheral nerve disorders, particularly diabetic neuropathy and motor neuron disease.
Threshold tracking measures membrane potential shifts, voltage-gated ion channels, and electrogenic pumps at stimulation sites, including regions beneath the myelin sheath.
The technique effectively identifies functional impairments in metabolic and toxic neuropathies but remains relatively insensitive to pure demyelinating pathology.

Cite This Study

Bostock et al. (1998) studied this question.

synapsesocial.com/papers/6a819d69ac3bbfe76d60ef14 https://doi.org/10.1002/(sici)1097-4598(199802)21:2<137::aid-mus1>3.0.co;2-c

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Implication

Review shows threshold tracking assesses axonal membrane excitability and ion channel activity in human nerves, indicating strong diagnostic utility in metabolic and toxic neuropathies.

Threshold tracking techniques in the study of human peripheral nerve

Discussion

Member takes

Implication

Key Points

Cite This Study

Threshold tracking techniques in the study of human peripheral nerve

Discussion

Member takes

Implication

Key Points

Cite This Study

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