Key result
The incidence of surgical intervention for mitral stenosis decreased from 3.3 to 2.2 cases per million person-years over 20 years, while three-year all-cause mortality remained stable.
Why the study?
To examine temporal changes in patient characteristics, the incidence rate of surgery, and the three-year mortality rate for patients undergoing surgery for mitral valve stenosis in Denmark from 2001 to 2021.
How have patient characteristics, incidence, and mortality for surgical intervention for mitral stenosis changed over time in Denmark?
Cohort (n=256)
Yes
How have patient characteristics, incidence, and mortality for surgical intervention for mitral stenosis changed over time in Denmark?
Hazard Ratio: 0.37 (95% CI 0.09–1.65)
Absolute Event Rate: 7% vs 14.3%
Over a 20-year period in Denmark, the incidence of surgery for mitral stenosis decreased significantly, accompanied by a reduction in comorbid heart failure, while three-year mortality remained stable.
Decreasing mitral stenosis surgery incidence may reflect shifting epidemiology; leaves open mortality drivers and needs confirmation beyond this cohort.
Aims: To examine temporal changes in patient characteristics, incidence rate of surgery, and three-year mortality rate for patients undergoing surgery for mitral valve stenosis in Denmark (2001-2021).. Methods and results: Utilizing Danish nationwide registries, we identified all adult patients undergoing first-time MS-intervention (2001-2021). Temporal changes across calendar periods were investigated (2001-2005, 2006-2010, 2011-2015, and 2016-2021). Using Kaplan-Meier estimates, we computed temporal changes in three-year all-cause mortality across calendar periods. With multivariable Cox regression analysis, we assessed adjusted rates of mortality. We included 256 patients (median age 60.3 years, 31.3% males). A decrease in the burden of chronic heart failure was identified (2001-2005:54%, and 2016-2021:20%, p-value<0.001), while the burden of atrial fibrillation seemed stable around 1 in 2. A decrease in rate of surgery was observed: 3.3 cases/million person-years (2001-2005), and 2.2 (2016-2021). The in-hospital mortality was 8.6% and the three-year mortality after discharge was 9.0%. We found no difference over calendar periods in crude estimates or adjusted analysis. Conclusion: From nationwide data (2001-2021), we identified the incidence of surgery, decreased significantly within the past 20 years while all-cause mortality remained stable. The burden of heart failure decreased while the burden of atrial fibrillation remained stable.
No takes yet. Share an insight, caveat, or question.
Due et al. (2023) conducted a cohort in Mitral valve stenosis (n=256). Surgical intervention for Mitral Stenosis (2016-2021) vs. Surgical intervention for Mitral Stenosis (2001-2005) was evaluated on Three-year all-cause mortality (HR 0.37, 95% CI 0.09-1.65). The incidence of surgical intervention for mitral stenosis decreased from 3.3 to 2.2 cases per million person-years over 20 years, while three-year all-cause mortality remained stable.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: