Key result
Among 1,052 patients hospitalized for acute heart failure in South Korea, the post-discharge 90-day mortality and heart failure readmission rates were 2.0% and 6.4%, respectively.
Why the study?
Heart failure is a leading cause of hospitalization and death worldwide, prompting the need to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute HF in South Korea.
Cohort (n=1,052)
Yes
The SMILE HF registry interim analysis provides contemporary data on the clinical characteristics, management, and early outcomes of acute heart failure patients in South Korea.
Background and Objectives: Heart failure (HF) is a leading cause of hospitalization and death worldwide. The Steady Movement with Innovating Leadership for Heart Failure (SMILE HF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute HF in South Korea. Methods: This prospective, observational multicenter cohort study was conducted on consecutive patients hospitalized for acute HF in nine university hospitals since September 2019. Enrolment of 2000 patients should be completed in 2024, and follow-up is planned through 2025. Results: Interim analysis of 1,052 consecutive patients was performed to understand the baseline characteristics. The mean age was 69±15 years; 57.6% were male. The mean left ventricular ejection fraction was 39±15%. The prevalences of HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction were 50.9%, 15.3%, and 29.2%. Ischemic cardiomyopathy (CMP) was the most common etiology (32%), followed by tachycardia-induced CMP (12.8%) and idiopathic dilated CMP (9.5%). The prescription rate of angiotensin-converting enzyme inhibitor/angiotensin receptor blockers/angiotensin receptor/neprilysin inhibitor, beta-blockers, spironolactone, and sodium-glucose cotransporter-2 inhibitors at discharge were 76.8%, 66.5%, 50.0%, and 17.5%, respectively. The post-discharge 90-day mortality and readmission rates due to HF aggravation were 2.0% and 6.4%, respectively. Our analysis reveals the current state of acute HF in South Korea. Conclusions: Our interim analysis provides valuable insights into the clinical characteristics, management, and early outcomes of acute HF patients in South Korea, highlighting the current state and treatment patterns in this population.
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Choi et al. (2024) conducted a cohort in Acute Heart Failure (n=1,052). Hospitalization for acute heart failure was evaluated on Post-discharge 90-day mortality and readmission due to heart failure aggravation. Among 1,052 patients hospitalized for acute heart failure in South Korea, the post-discharge 90-day mortality and heart failure readmission rates were 2.0% and 6.4%, respectively.
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