Key result
The prevalence of heart failure is increasing globally and in Korea due to an aging population, and while treatments for reduced ejection fraction have improved, therapies for preserved ejection fraction remain challenging.
Why the study?
Heart failure prevalence is rising with population aging, significant residual risk remains, benefits of current therapies are largely confined to reduced ejection fraction, and finding effective treatments for preserved ejection fraction remains challenging.
This review highlights the growing epidemiological burden of heart failure in Korea and globally, emphasizing the success of HFrEF therapies and the ongoing unmet need in HFpEF.
Highlights unmet HFpEF needs amid rising prevalence; leaves open targeted therapies for preserved ejection fraction.
Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body's needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of HF has been increasing in an aging society, including Korea. The vast advancement of medical and device therapy has improved the outcomes of HF, but significant residual risk still exists, and the benefit is confined to patients with reduced ejection fraction. Finding effective treatment for HF with preserved ejection fraction and identification of groups who benefit from drug and device therapy remain challenging. In this review, we illustrate the epidemiology, temporal trends, and current status of medical and device therapy, including heart transplantation, as well as emerging treatments for HF in Korea and worldwide.
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Park et al. (2020) conducted a review in Heart failure. The prevalence of heart failure is increasing globally and in Korea due to an aging population, and while treatments for reduced ejection fraction have improved, therapies for preserved ejection fraction remain challenging.
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