Key result
Instructing patients to swallow dabigatran capsules with a glassful of water significantly reduced upper gastrointestinal symptom scores (1.7 vs 5.0, p<0.01) on the Izumo scale compared to standard instructions.
Why the study?
Does instructing patients to swallow dabigatran capsules whole with a glassful of water reduce gastrointestinal adverse events and improve QOL in patients treated with dabigatran?
Observational (n=42)
Open-label
No
Does instructing patients to swallow dabigatran capsules whole with a glassful of water reduce gastrointestinal adverse events and improve QOL in patients treated with dabigatran?
Absolute Event Rate: 1.7% vs 5%
p-value: p=<0.01
Instructing patients to swallow dabigatran capsules whole with a glassful of water may reduce gastrointestinal adverse events and maintain patient quality of life.
Upper gastrointestinal symptoms, a common adverse effect of dabigatran, influence the continuation of medication. It has been speculated that this adverse effect can be reduced by changing the method of taking dabigatran: that is, to instruct patients to swallow dabigatran capsules whole with a glassful of water. However, there is no evidence to support this conclusion. Therefore, we changed our patient compliance instruction of dabigatran to the method mentioned above from September 2013 and investigated the effect of that change on the onset of adverse events and patient quality of life (QOL). Among 42 patients treated with dabigatran, 17 patients were categorized into the instruction change group and 25 were categorized into the no instruction change group. The Izumo scale was used to assess patient QOL. A total of 20 patients experienced side effects in the upper gastrointestinal tract (6 in the instruction change group, and 14 in the no instruction change group), and 18 patients in the lower gastrointestinal tract (3 in the instruction change group, and 15 in the no instruction change group). Izumo scale scores were significantly lower in the instruction change group than in the no instruction change group. Furthermore, in the no instruction change group, 5 patients showed a remarkable decrease in patient QOL by the adverse effects of gastrointestinal symptoms; however, in the instruction change group, this did not occur in any patients. The results indicate that patient QOL can be maintained by altering the method of taking dabigatran.
No takes yet. Share an insight, caveat, or question.
Yukita et al. (2014) conducted an observational in Atrial fibrillation (patients taking dabigatran) (n=42). Instruction to swallow dabigatran capsules whole with a glassful of water vs. Standard instruction (no instruction change) was evaluated on Upper gastrointestinal symptom score on the Izumo scale (p=<0.01). Instructing patients to swallow dabigatran capsules with a glassful of water significantly reduced upper gastrointestinal symptom scores (1.7 vs 5.0, p<0.01) on the Izumo scale compared to standard instructions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: