Key result
Hypertension consistently increased stroke risk across all older age groups, whereas diabetes mellitus increased stroke risk only in adults aged 60-74 years (HR 1.50) but not in those aged ≥75 years (HR 0.65, p=0.035 for interaction).
Why the study?
Are traditional risk factors differentially associated with stroke incidence in young-old (60-74 years) versus old-old (≥75 years) adults?
Cohort (n=2,065)
No
Are traditional risk factors differentially associated with stroke incidence in young-old (60-74 years) versus old-old (≥75 years) adults?
Hazard Ratio: 0.65 (95% CI 0.33–1.29)
p-value: p=0.035
Hypertension remains a significant stroke risk factor in both young-old and old-old adults, whereas diabetes mellitus only significantly increases stroke risk in the young-old population.
No takes yet. Share an insight, caveat, or question.
Hypertension may warrant continued stroke prevention focus in adults ≥75; leaves open diabetes relevance in the old-old.
Murakami et al. (2016) conducted a cohort in Stroke (n=2,065). Diabetes mellitus vs. Absence of diabetes mellitus was evaluated on First stroke incidence in adults aged ≥75 years (HR 0.65, 95% CI 0.33-1.29, p=0.035). Hypertension consistently increased stroke risk across all older age groups, whereas diabetes mellitus increased stroke risk only in adults aged 60-74 years (HR 1.50) but not in those aged ≥75 years (HR 0.65, p=0.035 for interaction).
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