Key result
Highest ADMA tertile linked to ~524% greater predicted 10-year stroke risk versus lowest tertile.
Why the study?
It is not currently known whether ADMA levels are related to the risk of stroke in Japanese women.
Is an elevated ADMA level associated with an increased predicted 10-year stroke risk in Japanese women?
Cross-Sectional (n=192)
No
Is an elevated ADMA level associated with an increased predicted 10-year stroke risk in Japanese women?
Odds Ratio: 6.24 (95% CI 1.13–34.5)
p-value: p=0.036
Elevated ADMA levels are significantly associated with an increased predicted 10-year stroke risk in Japanese women, suggesting its potential utility as a risk marker.
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May identify Japanese women at higher stroke risk; leaves open ADMA's incremental predictive value beyond standard factors.
Muraga et al. (2014) conducted a cross-sectional in Predicted stroke risk (n=192). Elevated Asymmetric Dimethylarginine (ADMA) level vs. Lowest ADMA level tertile was evaluated on High predicted 10-year stroke risk (≥5%) (OR 6.24, 95% CI 1.13-34.5, p=0.036). Elevated ADMA levels in the highest tertile were significantly associated with a high predicted 10-year stroke risk (OR 6.24) compared to the lowest tertile in Japanese women.
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