What question did this study set out to answer?

To compare systemic hemodynamic, volume, and endocrine characteristics between men and women with essential hypertension matched for blood pressure and clinical demographics.

August 1, 1987Annals of Internal Medicine

Disparate Cardiovascular Findings in Men and Women with Essential Hypertension

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Why the study?

Are there disparate cardiovascular and hemodynamic findings between men and women with essential hypertension?

Population

200 patients with essential hypertension

Design

Cross-sectional

Authors

FMFranz H. MesserliPreventive Cardiology

Discussion

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Implication

Sex-specific hemodynamics should not alter management; hypothesis-generating for outcome disparities and requires prospective validation.

Key Points

To compare systemic hemodynamic, volume, and endocrine characteristics between men and women with essential hypertension matched for blood pressure and clinical demographics.
Evaluated systemic hemodynamic, volume, and endocrine parameters in 100 hypertensive women matched 1:1 with 100 hypertensive men based on mean arterial pressure, age, race, and body surface area (N=200).
Measured resting parameters and blood pressure responses following isometric stress across premenopausal and postmenopausal subgroups.
Hypertensive women exhibited a higher resting heart rate, higher cardiac index, higher pulse pressure, and lower total peripheral resistance compared to matched men (all p < 0.01).
Isometric stress triggered an increase in arterial pressure that was almost 50% higher in men than in women.
Cardiovascular differences were statistically significant before menopause but not after menopause, showing women maintain lower peripheral resistance at any given arterial pressure.

Structured PICO

Are there disparate cardiovascular and hemodynamic findings between men and women with essential hypertension?

Population

200 patients with essential hypertension (100 women matched to 100 men by mean arterial pressure, age, race, and body surface area)

Outcome

Systemic hemodynamic, volume, and endocrine findings including resting heart rate, cardiac index, pulse pressure, and total peripheral resistancesurrogate

Premenopausal women with essential hypertension have lower total peripheral resistance and are hemodynamically younger than men of the same chronologic age, potentially explaining why hypertension is less lethal in women.

Cite This Study

Franz H. Messerli (1987) studied this question.

synapsesocial.com/papers/6a7ce9088acf2dd134cd8929 https://doi.org/10.7326/0003-4819-107-2-158

Topics

Hypertension management Women and heart disease

View Full Paper

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Bookmark

Disparate Cardiovascular Findings in Men and Women with Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Disparate Cardiovascular Findings in Men and Women with Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider