Key result
Female sex in untreated hypertension was associated with higher systemic vascular resistance, pulse pressure, and hormonal biomarkers, whereas men exhibited higher stroke volume and cardiac output.
Why the study?
Do the hemodynamic and hormonal mechanisms accounting for elevated arterial pressure in untreated essential hypertension differ between men and women?
Population
100 patients with untreated nondiabetic stage I and II prehypertension as defined by the Joint National…
Design
Cross-sectional
Authors
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May indicate sex-specific mechanisms in untreated hypertension; hypothesis-generating for tailored therapies pending prospective trials.
Cross-Sectional (n=100)
Do the hemodynamic and hormonal mechanisms accounting for elevated arterial pressure in untreated essential hypertension differ between men and women?
Significant sex differences exist in the hemodynamic and hormonal mechanisms underlying untreated essential hypertension, suggesting that tailored, sex-specific pharmacological approaches may be necessary for optimal blood pressure control.
Ferrario et al. (2013) conducted a cross-sectional in Untreated essential hypertension (n=100). Female sex vs. Male sex was evaluated on Hemodynamic and hormonal profile differences. Female sex in untreated hypertension was associated with higher systemic vascular resistance, pulse pressure, and hormonal biomarkers, whereas men exhibited higher stroke volume and cardiac output.
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