Key result
In patients with type 2 diabetes and hypertension, cardiac diastolic function (E/e' ratio) was independently associated with the GA/HbA1c ratio (β=0.519, p=0.002) and nighttime diastolic blood pressure variability (β=0.332, p=0.036).
Why the study?
The study was conducted to evaluate the effects of glucose metabolism and blood pressure variability on cardiac diastolic function in patients with type 2 diabetes mellitus and hypertension.
Cross-Sectional (n=23)
No
Effect estimate: β=0.519
p-value: p=0.002
In patients with type 2 diabetes mellitus and hypertension, increased glucose variability and nighttime diastolic blood pressure variability are independently associated with worse cardiac diastolic function.
May link glycemic and BP variability to diastolic dysfunction in T2DM hypertension; leaves open need for prospective confirmation before practice change.
We evaluated the effects of glucose metabolism and blood pressure（BP） variability on cardiac diastolic function in patients with type 2 diabetes mellitus（T2DM） and hypertension. A total of 23 inpatients with T2DM underwent ambulatory BP monitoring（ABPM） and echocardiography. BP variability was assessed by measuring the mean BP and the standard deviation（SD） of systolic and diastolic BP over 24 hours, as well as daytime and nighttime ABPM. Cardiac diastolic function was assessed using the echocardiography E/e′ ratio. Participants had a mean age of 69.0±10.6 years, disease duration of 11.0±10.5 years, glycated hemoglobin（HbA1c） of 8.2％±1.3％, and glycated albumin（GA） of 22.0％±4.2％. Univariate analysis showed that the nighttime systolic BP, nighttime SDs of systolic and diastolic BP, urinary albumin, estimated glomerular filtration rate, and GA/HbA1c ratio were all significantly correlated with the E/e′ ratio. Moreover, stepwise multiple regression analysis identified nighttime SD of diastolic BP, urinary albumin, and GA/HbA1c ratio as independent contributors to the E/e′ ratio. In patients with T2DM and hypertension, cardiac diastolic function was associated with nighttime diastolic BP variability and the GA/HbA1c ratio.
No takes yet. Share an insight, caveat, or question.
Goto et al. (2019) conducted a cross-sectional in Type 2 diabetes mellitus and hypertension (n=23). Glucose variability (GA/HbA1c ratio) and blood pressure variability was evaluated on Cardiac diastolic function (E/e' ratio) (β=0.519, p=0.002). In patients with type 2 diabetes and hypertension, cardiac diastolic function (E/e' ratio) was independently associated with the GA/HbA1c ratio (β=0.519, p=0.002) and nighttime diastolic blood pressure variability (β=0.332, p=0.036).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: