What question did this study set out to answer?

To determine whether short-term blood pressure variability and abnormal diurnal blood pressure patterns predict incident cardiovascular disease in patients with type 2 diabetes.

October 2, 2008American Journal of HypertensionOpen Access

Night Time Blood Pressure Variability Is a Strong Predictor for Cardiovascular Events in Patients With Type 2 Diabetes

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Why the study?

Does night time blood pressure variability predict incident cardiovascular disease in patients with type 2 diabetes?

Population

300 patients with uncomplicated type 2 diabetes without known cardiovascular disease and without blood…

Design

Cohort

Follow-up

54 +/- 20 months

Authors

KEKatsumi EguchiKanazawa University JIJoji IshikawaTokyo Metropolitan Institute of Gerontology SHSatoshi HoshidePreventive Cardiology

Discussion

Member takes

Implication

Nighttime BP variability may stratify CVD risk in T2D; hypothesis-generating and requires prospective validation before clinical use.

Key Points

To determine whether short-term blood pressure variability and abnormal diurnal blood pressure patterns predict incident cardiovascular disease in patients with type 2 diabetes.
Monitored ambulatory blood pressure in 300 patients with uncomplicated type 2 diabetes without previous cardiovascular disease or antihypertensive therapy over a mean follow-up of 54 ± 20 months.
Calculated standard deviations of awake and asleep blood pressure and classified diurnal patterns (nondipper, riser, morning surge), evaluating cardiovascular risk with multivariable Cox proportional hazards models.
Over the follow-up period, 29 incident cardiovascular events occurred.
Higher standard deviations of sleep systolic blood pressure (HR = 1.08; 95% CI, 1.01–1.16, P < 0.05) and sleep diastolic blood pressure (HR = 1.13; 95% CI, 1.04–1.23, P < 0.01) independently predicted incident cardiovascular disease.
Nondipper, riser, and morning surge patterns showed no independent association with cardiovascular events after adjusting for clinic and 24-hour blood pressure levels.

Structured PICO

Does night time blood pressure variability predict incident cardiovascular disease in patients with type 2 diabetes?

Population

300 patients with uncomplicated type 2 diabetes (T2DM) without known cardiovascular disease and without blood pressure medications, mean age 67.8 +/- 9.6 years, 48% male, 84% with a diagnosis of hypertension.

Intervention

Ambulatory blood pressure monitoring (ABPM) to assess short-term blood pressure variability and abnormal patterns of diurnal BP variation (nondipper, riser, or morning BP surge).

Outcome

Incident cardiovascular disease (CVD)hard clinical

Night time blood pressure variability, but not abnormal diurnal BP variation patterns, is an independent predictor of future cardiovascular events in patients with type 2 diabetes.

Cite This Study

Eguchi et al. (2008) studied this question.

synapsesocial.com/papers/6a7bbd54b6db831c5f75d673 https://doi.org/10.1038/ajh.2008.294

Topics

Hypertension management

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Night Time Blood Pressure Variability Is a Strong Predictor for Cardiovascular Events in Patients With Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Night Time Blood Pressure Variability Is a Strong Predictor for Cardiovascular Events in Patients With Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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