What is the clinical evidence from this study?

Study design: Cohort. Population: Congenital heart defects (n=317538). Intervention: Congenital heart defects. Primary outcome: Prevalence, timing of diagnosis and infant mortality.

What question did this study set out to answer?

To assess the prevalence, diagnostic timing, and infant mortality of congenital heart defects using an anatomic and clinical classification system.

August 11, 2012Heart

Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a population-based study

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Key result

Congenital heart defects had a total prevalence of 90 per 10,000 births, with an infant mortality rate of 8.5% for isolated defects excluding ventricular septal defects.

Population

All cases diagnosed prenatally or up to 1 year of age in birth cohorts for women in Greater Paris, yielding…

Design

Cohort

Follow-up

up to 1 year of age

Authors

BKBabak KhoshnoodInserm NLNathalie LelongInserm LHLucile HouyelPediatric / Congenital Cardiology

Discussion

Member takes

Implication

Supports tailored prognostic counseling by anatomic category; extends ACC-CHD utility but leaves open prospective validation.

Key Points

To assess the prevalence, diagnostic timing, and infant mortality of congenital heart defects using an anatomic and clinical classification system.
Population-based cohort study evaluating 317,538 births in Greater Paris between May 2005 and April 2008.
Included all congenital heart defect cases among live births, terminations of pregnancy for foetal anomaly, and foetal deaths diagnosed prenatally or up to 1 year of age.
Diagnoses were confirmed at specialised centres and classified into categories based on anatomic and clinical criteria (ACC-CHD).
Identified 2,867 congenital heart defect cases across 317,538 births (total prevalence 90 per 10,000), comprising 2,348 live births (82.0%), 466 pregnancy terminations (16.2%), and 53 foetal deaths (1.8%).
Excluding ventricular septal defects, 40% of isolated cases were diagnosed prenatally, about 50% of the remainder within 7 days, and 20% after the fourth week of life.
Infant mortality for isolated defects (excluding ventricular septal defects) was 8.5%, with 40% of deaths occurring after the fourth week of life.

Study Design

Type

Cohort (n=317,538)

Multicenter

Yes

Structured PICO

Population

317,538 births in Greater Paris yielding 2,867 cases of congenital heart defects diagnosed prenatally or up to 1 year of age.

Outcome

Prevalence, timing of diagnosis, and infant mortality of congenital heart defectshard clinical

The prevalence, timing of diagnosis, and infant mortality of congenital heart defects vary substantially across anatomic and clinical categories, highlighting the utility of the ACC-CHD classification for predicting outcomes.

Cite This Study

Khoshnood et al. (2012) conducted a cohort in Congenital heart defects (n=317,538). Congenital heart defects was evaluated on Prevalence, timing of diagnosis and infant mortality. Congenital heart defects had a total prevalence of 90 per 10,000 births, with an infant mortality rate of 8.5% for isolated defects excluding ventricular septal defects.

synapsesocial.com/papers/6a81a0c328bb6950eb60f4b5 https://doi.org/10.1136/heartjnl-2012-302543

Topics

Congenital heart disease adults

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Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a population-based study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a population-based study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

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