What question did this study set out to answer?

To assess international trends and patterns in the prenatal diagnosis of critical congenital heart defects and determine their relationship to total prevalence, live birth prevalence, and mortality.

July 1, 2019BMJ OpenOpen Access

Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study

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Why the study?

To evaluate international trends and patterns of prenatal diagnosis of critical congenital heart defects and examine their relationship to total and live birth prevalence and mortality.

Population

18 243 CCHD cases among 8 847 081 births across 12 countries

Design

International retrospective cohort study

Authors

MBMarian K. BakkerOslo University Hospital JBJorieke E. H. BergmanUniversity Medical Center Groningen SKSergey KrikovUniversity of Utah

Discussion

Member takes

Implication

Wide variation and rising prenatal CCHD detection rates warrant standardized screening protocols; leaves open effects on live birth prevalence and mortality.

Key Points

To assess international trends and patterns in the prenatal diagnosis of critical congenital heart defects and determine their relationship to total prevalence, live birth prevalence, and mortality.
International retrospective cohort study examining data from 15 birth defect surveillance programmes across 12 countries in Europe, North America, South America, and Asia from delivery years 2000 to 2014.
Evaluated 18,243 cases diagnosed with 1 of 12 critical congenital heart defects (CCHDs) among a total denominator of 8,847,081 births, including live births, stillbirths, and elective terminations of pregnancy for fetal anomaly.
Median total CCHD prevalence was 19.1 per 10,000 births, exhibiting a threefold variation between programmes from 10.1 to 31.0 per 10,000 births.
Prenatal detection rates reached at least 50% in one-third of the programmes but showed marked regional disparity, ranging from 13% in the Slovak Republic to 87% in parts of France.
Prenatal detection was highest for hypoplastic left heart syndrome (64% overall) and lowest for total anomalous pulmonary venous return (28% overall), with an increasing detection trend observed across most programmes.

Structured PICO

Population

18,243 cases of critical congenital heart defects (CCHDs) among 8,847,081 births (including live births, stillbirths, and elective terminations of pregnancy for fetal anomaly) from 15 birth defect surveillance programmes in 12 countries across Europe, North and South America, and Asia for delivery years 2000 to 2014.

Outcome

International trends and patterns of prenatal diagnosis of CCHDs and their relation to total and live birth CCHD prevalence and mortality

Prenatal detection of critical congenital heart defects accounts for at least 50% of cases in many regions and is increasing, though significant geographic variability exists due to local policies and access.

Cite This Study

Bakker et al. (2019) studied this question.

synapsesocial.com/papers/6a7cbe1f273accedbda8b294 https://doi.org/10.1136/bmjopen-2018-028139

Topics

Congenital heart disease adults

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Implication

Wide variation and rising prenatal CCHD detection rates warrant standardized screening protocols; leaves open effects on live birth prevalence and mortality.

Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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