Key result
An elevated neutrophil to lymphocyte ratio was identified as a significant independent predictor of poor functional capacity (<5 MET) in patients with compensated heart failure (OR 3.085).
Why the study?
Does a higher neutrophil to lymphocyte ratio predict poor functional capacity in patients with compensated heart failure?
Cross-Sectional (n=164)
No
Does a higher neutrophil to lymphocyte ratio predict poor functional capacity in patients with compensated heart failure?
An elevated neutrophil to lymphocyte ratio is a strong predictor of poor functional capacity in patients with compensated heart failure.
Elevated NLR may flag poor functional capacity risk in compensated HF; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVES: We aimed to assess the relationship between neutrophil to lymphocyte ratio (N/L ratio) and functional capacity (FC) of patients with compensated heart failure (CHF). STUDY DESIGN: A total of 94 consecutive CHF patients and age-gender matched 70 subjects with normal echocardiographic examination were enrolled. Peripheral venous blood samples were drawn before echocardiography examination and treadmill test in all study population. The treadmill test based on modified Bruce protocol was used to determine the functional status of CHF patients. Poor FC was defined as <5 metabolic equivalant (MET) in the exercise test. Afterwards, patients with CHF were divided into two groups with respect to the top and bottom 3 of the N/L ratio. RESULTS: FC (3.2 ± 2.05 MET vs. 6.1 ± 2.04 MET, p<0.001), ejection fraction (%31.5 ± 7.64 vs. %34.8 ± 6.82, p=0.028) were found to be lower and N-terminal pro-brain natriuretic peptide (NT-proBNP) level (3360 ± 2742 pg/dl vs. 1613 ± 1334 pg/dl, p<0.001) pulmonary artery pressure (46.3 ± 11.50 mmHg vs. 41.5 ± 9.45 mmHg, p=0.049), left atrial diameters (4.6 ± 0.52 cm vs. 4.3 ± 0.43 cm, p=0.005), E/Ea ratio (12.2 ± 4.37 vs. 9.2 ± 3.20, p<0.001) were found to be higher in CHF patients with an N/L ratio >3 than with an N/L ratio <3. The N/L ratio, and log-NT-proBNP level were determined to be a predictive factor of poor FC (odds ratio [OR]=3.085, 95% confidence interval [CI]= 1.520-6.260, p=0.002 and OR=1.585, 95% CI=1.201-2.091, p=0.001, respectively). A cut-off point of 2.74 for the N/L ratio had 79.4% sensitivity and 80% specificity in predicting poor FC. CONCLUSION: N/L ratio can be used to predict poor FC in patients with CHF.
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Musa Çakıcı (2014) conducted a cross-sectional in Compensated heart failure (n=164). Neutrophil to lymphocyte ratio (N/L ratio) vs. Lower N/L ratio was evaluated on Poor functional capacity (<5 MET) (OR 3.085, 95% CI 1.520-6.260, p=0.002). An elevated neutrophil to lymphocyte ratio was identified as a significant independent predictor of poor functional capacity (<5 MET) in patients with compensated heart failure (OR 3.085).
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