Key result
A neutrophil-lymphocyte ratio cutoff of 2.56 predicted severe rheumatic mitral stenosis with a sensitivity of 75% and specificity of 74%.
Why the study?
Is the neutrophil-lymphocyte ratio associated with the presence and severity of rheumatic mitral valve stenosis?
Observational (n=227)
Is the neutrophil-lymphocyte ratio associated with the presence and severity of rheumatic mitral valve stenosis?
The neutrophil-lymphocyte ratio is an inexpensive and accessible marker that may help predict the presence and severity of mitral stenosis in patients with rheumatic mitral valvular disease.
Answers are grounded in this paper and cite their sources.
May support NLR as accessible marker for severe rheumatic MS; hypothesis-generating, requires prospective validation before clinical use.
The aim of the study is to investigate the association between the severity of rheumatic mitral valvular disease (RMVD) and the neutrophil-lymphocyte ratio (NLR). A total of 227 patients were enrolled in the study and divided into 3 groups. Patients in group 1 had rheumatic mitral stenosis (RMS), those in group 2 had RMVD without stenosis, and those in group 3 served as the control group. Group 1 was further divided into 2 groups, severe mitral stenosis (MS) and mild to moderate MS. The NLR was significantly higher in patients with severe MS when compared to those with mild to moderate MS (P = .002) while lymphocyte count was lower (P = .034). Using a cutoff level of 2.56, the NLR predicted severe RMS with a sensitivity of 75% and specificity of 74%. In conclusion, as an inexpensive, simple, and accessible marker of inflammation, the NLR may be useful in predicting the presence and severity of MS in patients with RMVD.
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Polat et al. (2013) conducted an observational in Rheumatic mitral valvular disease (n=227). Neutrophil-lymphocyte ratio (NLR) vs. Mild to moderate MS and controls was evaluated on Severe rheumatic mitral stenosis (Sensitivity 75%, Specificity 74%, p=.002). A neutrophil-lymphocyte ratio cutoff of 2.56 predicted severe rheumatic mitral stenosis with a sensitivity of 75% and specificity of 74%.
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