November 1, 2004Platelets
The PFA-100® detects sub-optimal antiplatelet responses in patients on aspirin
Why the study?
Does the PFA-100 detect sub-optimal antiplatelet responses to aspirin in patients with a previous ACS?
Population
100 patients taking aspirin 100 mg/day assessed at 1 and 6 months after a first acute coronary syndrome (ACS)
Comparison
Platelet Function Analyzer (PFA-100) testing vs Conventional aggregometry
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Overview
Confirmed SASAR by both tests associated with higher mortality; leaves open whether PFA-100 testing improves outcomes.
Structured PICO
Does the PFA-100 detect sub-optimal antiplatelet responses to aspirin in patients with a previous ACS?
P
Population
100 patients taking aspirin 100 mg/day assessed at 1 and 6 months after a first acute coronary syndrome (ACS)
I
Intervention
Platelet Function Analyzer (PFA-100) testing
C
Comparator
Conventional aggregometry
O
Outcome
Sub-optimal response to aspirin (SASAR) defined as failure to significantly prolong closure timesurrogate
The PFA-100 detects a high rate of sub-optimal antiplatelet response to aspirin in ACS patients, which may be associated with increased mortality.
Cite This Study
Sambola et al. (2004) studied this question.