January 1, 2002Platelets

Monitoring of antiplatelet therapy with the PFA-100® in peripheral angioplasty patients

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Why the study?

Does platelet function monitoring with PFA-100 predict restenosis or reocclusion in PAOD patients undergoing PTA?

Population

98 patients with peripheral arterial occlusive disease undergoing elective percutaneous transluminal…

Comparison

Monitoring platelet function with the PFA-100… vs Responders to antiplatelet therapy.

Design

Cohort

Follow-up

12 months

Authors

SZS. ZieglerUniversitätszahnklinik Wien TMThomas MacaUniversity of Vienna EAElisabeth AltUniversity of Vienna

Discussion

Member takes

Implication

PFA-100 non-response was associated with higher restenosis risk after PTA; hypothesis-generating and should not yet change practice.

Structured PICO

Does platelet function monitoring with PFA-100 predict restenosis or reocclusion in PAOD patients undergoing PTA?

Population

98 patients (43 females, 55 males) with peripheral arterial occlusive disease (PAOD) undergoing elective percutaneous transluminal angioplasty (PTA) of the lower extremities, treated with aspirin (n=52), thienopyridine (n=34), or combination therapy (n=12).

Intervention

Monitoring platelet function with the PFA-100 system in 3-month intervals over 1 year to identify non-responders to antiplatelet therapy.

Comparator

Responders to antiplatelet therapy (specifically clopidogrel).

Outcome

Occurrence of restenosis or reocclusion at the site of angioplasty over 12 months.surrogate

Monitoring platelet function with PFA-100 may help identify patients on clopidogrel at elevated risk for restenosis or reocclusion after peripheral angioplasty.

Cite This Study

Ziegler et al. (2002) studied this question.

synapsesocial.com/papers/6a879a1c3a4719e3ff7d69db https://doi.org/10.1080/0953710021000057866

Topics

Dual antiplatelet therapy

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Monitoring of antiplatelet therapy with the PFA-100® in peripheral angioplasty patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Monitoring of antiplatelet therapy with the PFA-100® in peripheral angioplasty patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider