What question did this study set out to answer?

To determine the quantity and time course of platelet accumulation at angioplasty sites and examine its association with restenosis in human peripheral arteries.

March 1, 1989Radiology

Platelet deposition at angioplasty sites and its relation to restenosis in human iliac and femoropopliteal arteries.

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Why the study?

Does high dose aspirin compared to low dose aspirin reduce platelet deposition and restenosis in patients undergoing peripheral artery angioplasty?

Population

92 patients undergoing percutaneous transluminal angioplasty in peripheral arteries

Comparison

High dose aspirin vs Low dose aspirin

Design

Cohort

Follow-up

median 14 months

Authors

EME MinarMedical University of Vienna HEH EhringerUniversity of Vienna RAR AhmadiCarleton University

Discussion

Member takes

Implication

Platelet deposition after peripheral angioplasty was not associated with restenosis; leaves open whether aspirin prevents restenosis via this mechanism.

Key Points

To determine the quantity and time course of platelet accumulation at angioplasty sites and examine its association with restenosis in human peripheral arteries.
Evaluated 92 patients undergoing percutaneous transluminal angioplasty (PTA) in iliac and femoropopliteal arteries who received high-dose or low-dose aspirin.
Quantified platelet deposition using dual-radiotracer scintigraphy to calculate the platelet accumulation index (PAI) at 4–6 hours and subsequent days post-PTA, with a median follow-up of 14 months for 67 femoropopliteal segment patients.
Platelet accumulation peaked at 4–6 hours post-PTA compared with subsequent days (P < .05), with no difference in accumulation between high-dose and low-dose aspirin regimens.
Restenosis occurred in 21 of 67 femoropopliteal patients over 14 months of follow-up.
Median PAI at 4–6 hours and 22–24 hours was significantly lower in the 21 patients who developed restenosis compared with the 46 patients who did not.

Structured PICO

Does high dose aspirin compared to low dose aspirin reduce platelet deposition and restenosis in patients undergoing peripheral artery angioplasty?

Population

92 patients undergoing percutaneous transluminal angioplasty (PTA) in peripheral arteries (iliac and femoropopliteal)

Intervention

High dose aspirin

Comparator

Low dose aspirin

Outcome

Platelet accumulation index (PAI) quantitated by dual-radiotracer scintigraphy and restenosissurrogate

Platelet deposition after peripheral angioplasty is not associated with increased restenosis, suggesting antiplatelet agents targeting this mechanism may not prevent restenosis.

Cite This Study

Minar et al. (1989) studied this question.

synapsesocial.com/papers/6a97600e3cd4aac86e7fd95e https://doi.org/10.1148/radiology.170.3.2521736

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Implication

Platelet deposition after peripheral angioplasty was not associated with restenosis; leaves open whether aspirin prevents restenosis via this mechanism.

Platelet deposition at angioplasty sites and its relation to restenosis in human iliac and femoropopliteal arteries.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Platelet deposition at angioplasty sites and its relation to restenosis in human iliac and femoropopliteal arteries.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider