Key result
Percutaneous transluminal angioplasty significantly increased platelet deposition at the angioplasty site (median target/non-target ratio 1.53 vs 1.0 before PTA; p<0.0005).
Why the study?
Does percutaneous transluminal angioplasty increase platelet deposition and turnover in patients with lower extremity arterial disease on high-dose aspirin therapy?
Population
20 patients undergoing percutaneous transluminal angioplasty of iliac and femoral arteries, on ASA therapy
Comparison
Percutaneous transluminal angioplasty (PTA) vs Pre-PTA baseline (before and after comparison)
Design
Cohort
Follow-up
24 hours
Authors
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PTA was associated with increased local platelet deposition despite high-dose aspirin; leaves open whether intensified antiplatelet regimens are warranted post-procedure.
Observational (n=20)
Does percutaneous transluminal angioplasty increase platelet deposition and turnover in patients with lower extremity arterial disease on high-dose aspirin therapy?
Absolute Event Rate: 1.53% vs 1%
p-value: p=<0.0005
PTA of lower extremity arteries significantly increases local platelet deposition and platelet turnover despite high-dose aspirin therapy.
Minar et al. (1987) conducted an observational in Patients undergoing percutaneous transluminal angioplasty (PTA) in iliac and femoral arteries (n=20). Percutaneous transluminal angioplasty (PTA) vs. Before PTA was evaluated on Median target/non-target ratio of platelet deposition (p=<0.0005). Percutaneous transluminal angioplasty significantly increased platelet deposition at the angioplasty site (median target/non-target ratio 1.53 vs 1.0 before PTA; p<0.0005).
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