Population
Submitochondrial particles isolated from pig heart and isolated guinea-pig ventricular myocytes
Design
Preclinical
Authors
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Challenges K(ATP)-only models of diazoxide cardioprotection; leaves open human translation and clinical relevance.
Diazoxide and 5-HD have K(ATP) channel-independent targets in the heart, challenging the assumption that their cardioprotective effects are solely mediated by mitochondrial K(ATP) channels.
Hanley et al. (2002) studied this question.
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