This case report describes a previously unreported presentation of primary cardiac lymphoma as a noninvasive fibrin thrombus mimicking a myxoma and causing an embolic stroke.
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May expand differential for cardiac thrombi in embolic stroke; leaves open whether this represents a distinct lymphoma subtype.
An immunocompetent 29-year-old male presented with an embolic stroke from an unusual primary cardiac lymphoma. The cardiac lesion consisted of a polypoid, left atrial, mural fibrin thrombus with anaplastic tumor cells lining the surface of the clot. Histologic, immunophenotypic, and molecular characterizations were consistent with a diagnosis of CD30+ large B-cell lymphoma with anaplastic cytology. While tumor emboli from invasive primary cardiac lymphomas have been reported, this noninvasive fibrin thrombus-associated lymphoma appears to be unique and previously unreported.
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Quigley et al. (2003) studied this question.
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