Key result
Among 174 differentially expressed proteins, 46 increased more than twofold in acute aortic dissection, with Lumican significantly elevated compared to healthy and myocardial infarction controls.
Why the study?
Is Lumican a potential serum biomarker for diagnosing acute aortic dissection?
Population
120 subjects including patients with acute aortic dissection, acute myocardial infarction, and healthy…
Comparison
Serum biomarker analysis using isobaric tags for… vs Serum from patients with acute myocardial…
Design
Case-control
Authors
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May support Lumican as a diagnostic biomarker for acute aortic dissection; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=120)
Is Lumican a potential serum biomarker for diagnosing acute aortic dissection?
Lumican was identified as a potential serum biomarker that may assist in the diagnosis of acute aortic dissection.
Gu et al. (2011) conducted a case-control in Acute aortic dissection (n=120). Acute aortic dissection vs. Acute myocardial infarction and healthy volunteers was evaluated on Differentially expressed serum proteins. Among 174 differentially expressed proteins, 46 increased more than twofold in acute aortic dissection, with Lumican significantly elevated compared to healthy and myocardial infarction controls.
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