Key result
A biomarker model combining D-dimers, hs-TnT, IL-6, and PAI1 correctly classifies 75% of AAD cases.
Why the study?
Acute aortic dissection is a life-threatening cause of acute chest pain, but there has been no specific blood test in its diagnostic workup.
Do novel blood biomarkers (IL-10, IL-6, PAI1) improve the diagnostic discrimination of acute aortic dissection in patients presenting with acute chest pain?
Observational
Do novel blood biomarkers (IL-10, IL-6, PAI1) improve the diagnostic discrimination of acute aortic dissection in patients presenting with acute chest pain?
IL-10 alone or a multi-marker panel including IL-6 and PAI1 alongside D-dimers and hs-TnT may improve the diagnostic discrimination of acute aortic dissection from other causes of acute chest pain.
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Plasma biomarker candidates for AAD require validation; leaves open diagnostic utility versus AMI and PE.
Forrer et al. (2021) conducted an observational in Acute aortic dissection. Blood biomarkers (IL-10, IL-6, PAI1, hs-TnT, D-dimers) was evaluated on Diagnostic accuracy for acute aortic dissection. A biomarker model combining D-dimers, hs-TnT, IL-6, and PAI1 correctly classified 75% of acute aortic dissection cases, delivering 83% sensitivity and 95% specificity for its diagnosis.
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