Why the study?
Acute aortic dissection is an emergency disease with high misdiagnosis rate and mortality, and the impact of blood-related biomarkers, specifically D-dimer, on in-hospital outcomes needed exploration.
Do admission plasma biomarkers (D-dimer, LDL-C) predict in-hospital mortality in patients with acute aortic dissection?
Population
345 patients with AAD in a single hospital
Comparison
Biomarker levels including D-dimer (cutoff 5.9mg/l) and LDL-C (cutoff 1.45 mg/l)
Design
Single-center observational study
Authors
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May support D-dimer for AAD risk stratification; leaves open prospective validation before practice change.
Do admission plasma biomarkers (D-dimer, LDL-C) predict in-hospital mortality in patients with acute aortic dissection?
Admission D-dimer ≥5.9 mg/L is an independent predictor of in-hospital mortality in patients with acute aortic dissection, particularly type A.
Xie et al. (2021) studied this question.
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