Key result
D-dimer rules out acute aortic dissection with ~95% pooled sensitivity.
Why the study?
The diagnostic accuracy of D-dimer levels for acute aortic dissection (AAD) required quantitative synthesis to clarify sensitivity and specificity.
Population
274 AAD patients and 469 controls from 5 studies
Comparison
D-dimer levels in AAD patients versus controls
Design
Meta-analysis of 5 diagnostic accuracy studies
Authors
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May support D-dimer to rule out acute aortic dissection; leaves open prospective validation before clinical adoption.
Meta-Analysis (n=743)
Effect estimate: Sensitivity 94.5% (95% CI 78.1%-98.8%)
p-value: p=<0.001
Cui et al. (2015) conducted a meta-analysis in Acute aortic dissection (n=743). D-dimer levels vs. Patients without acute aortic dissection was evaluated on Pooled sensitivity of D-dimer levels for diagnosing acute aortic dissection (Sensitivity 94.5%, 95% CI 78.1%-98.8%, p=<0.001). D-dimer levels demonstrated a pooled sensitivity of 94.5% and specificity of 69.1% for diagnosing acute aortic dissection, indicating its utility as a negative marker for ruling out the disease.
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