Key result
D-Dimer levels were positive in 100% of patients with acute aortic dissection compared to 36% of controls, demonstrating 100% sensitivity and 64% specificity for diagnosis within 24 hours of symptom onset.
Why the study?
Diagnostic imaging for acute aortic dissection is limited by availability, creating a need for a fast, cost-effective, and technically simple diagnostic method.
Does D-Dimer measurement accurately diagnose acute aortic dissection in patients presenting with clinical suspicion within 24 hours of symptom onset?
Population
45 patients with clinical suspicion of AAD presenting within 24 hours from symptom onset
Comparison
Patients with confirmed AAD by TEE vs patients with other final diagnoses
Design
Prospective study
Authors
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May aid ruling out acute aortic dissection with negative D-dimer; hypothesis-generating and requires prospective validation.
Observational (n=45)
No
Does D-Dimer measurement accurately diagnose acute aortic dissection in patients presenting with clinical suspicion within 24 hours of symptom onset?
Effect estimate: Sensitivity 100%, Specificity 64%
Absolute Event Rate: 100% vs 36%
p-value: p=<0.001
A negative D-Dimer test within 24 hours of symptom onset is highly sensitive (100%) and can effectively rule out acute aortic dissection, though its specificity is moderate (64%).
Rafla et al. (2021) conducted an observational in Acute Aortic Dissection (n=45). D-Dimer level ≥0.5 ug/ml vs. Patients with other final diagnoses (non-AAD) was evaluated on Positive D-Dimer level (≥0.5 ug/ml) (Sensitivity 100%, Specificity 64%, p=<0.001). D-Dimer levels were positive in 100% of patients with acute aortic dissection compared to 36% of controls, demonstrating 100% sensitivity and 64% specificity for diagnosis within 24 hours of symptom onset.
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